WebJan 15, 2024 · SDF-1α, the most common isoform of stromal cell-derived factor 1, has shown vital effects in regulating chondrocyte proliferation, maturation, and chondrogenesis. Autophagy is a highly conserved biological process to help chondrocytes survive in harsh environments. However, the effect of SDF-1α on chondrocyte autophagy is still … WebBased on cluster-specific regulatory networks, protein activity was inferred for scRNA-seq data by a final metaVIPER algorithm run. ... WSB1, JMJD6, TSPYL2, HMGB2) and chondrocyte senescence marker proteins (SOX9, COL10A1). This may be partly caused by the insufficient sequencing depth and high dropout rate of scRNA-seq. Furthermore, a …
Gene expression profiling of chondrogenic differentiation …
WebApr 6, 2024 · Chondrogenic transcription factor SOX9 and cartilage matrix specific markers ACAN and COL2A1 were expressed in chondrocytes (Figure 1C). 5 We identified EC1/2 by expression of feature genes including CDH5, CD34 and PECAM1, pericytes by ACTA2, MYH11 and TAGLN (Figure 1C). 25-29 FAP, FBLN1 and COL1A2 were specifically … WebChondrocytes are the only type of cells found in cartilage. Chondrocytes have different morphologies due to their different locations in cartilage. Juvenile chondrocytes are … gartlwasserfall
A high-resolution route map reveals distinct stages of chondrocyte ...
WebJan 30, 2007 · Flow cytometry analysis showed that CD44, CD151, and CD49c were expressed at significantly higher levels in chondrocytes with higher chondrogenic … WebChondrocytes, which differentiate following the condensation of mesenchymal stem cells, are responsible for the secretion of extracellular matrix molecules, such as collagens and proteoglycans. Transcription factor SOX9 is critical for … WebHigh-density cultures are widely used as an in vitro model for studies of embryonic cartilage formation. In the present study we investigated the suitability of high-density cultures for the redifferentiation of dedifferentiated chondrocytes. When primary human chondrocytes were cultured in alginate beads, some cells emigrated into Petri dishes. gartlove country kennels