WebJ. Petkova, K.D. Friedman, in Comprehensive Toxicology (Third Edition), 2024 12.15.6 Factor X Deficiency. Factor X (Stuart–Prower factor) is a vitamin K-dependent clotting factor. It plays a central role in the coagulation cascade at the point of convergence of the intrinsic and extrinsic pathways. Factor IX (or Christmas factor) (EC 3.4.21.22) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes haemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to … See more Factor IX is produced as a zymogen, an inactive precursor. It is processed to remove the signal peptide, glycosylated and then cleaved by factor XIa (of the contact pathway) or factor VIIa (of the tissue factor pathway) to … See more The gene for factor IX is located on the X chromosome (Xq27.1-q27.2) and is therefore X-linked recessive: mutations in this gene affect males much more frequently than females. At least 534 disease-causing mutations in this gene have been … See more • Davie EW, Fujikawa K (1975). "Basic mechanisms in blood coagulation". Annual Review of Biochemistry. 44: 799–829. doi: • Sommer SS (Jul … See more Factors VII, IX, and X all play key roles in blood coagulation and also share a common domain architecture. The factor IX protein is composed of four protein domains: … See more Deficiency of factor IX causes Christmas disease (hemophilia B). Over 3000 variants of factor IX have been described, affecting 73% of … See more • "Coagulation Factor IX (Recombinant), Fc Fusion Protein". Drug Information Portal. U.S. National Library of Medicine. • "Eftrenonacog alfa". … See more
Christmas factor Definition & Meaning - Merriam-Webster
WebAug 30, 2024 · Factor IX is a blood-clotting factor that promotes healing and helps the body seal wounds. Without it, the body struggles to effectively stop the flow of blood from a wound, injury, or bleeding site. As a result, people who have hemophilia B bruise easily and bleed for longer periods of time. WebThe meaning of CHRISTMAS FACTOR is factor IX. city of woodstock concert series
The Christmas Factor Issue 41 of Protein Spotlight
WebDec 12, 2003 · The Christmas factor (also known as factor IX, or FIX) is involved in the blood clotting process and its deficiency causes the rare form of congenital male … WebAug 29, 2024 · The mechanism by which coagulation allows for hemostasis is an intricate process that is done through a series of clotting factors. The intrinsic pathway consists of factors I, II, IX, X, XI, and XII. … WebJul 21, 2024 · The primary cause of factor XI deficiency is an abnormal change, called a mutation, in the genes that regulate the formation of clotting factors in the blood. Clotting factors help form clots and ... city of woodstock fire department