WebJul 1, 2005 · Capecitabine is readily absorbed from the gastrointestinal tract and activated, through a series of enzymatic reactions occurring first in the liver and subsequently in most tissues (including tumor tissue), to the active drug 5-FU. It is catabolized by DPD as described above. WebMar 29, 2015 · The vinorelbine–cisplatin regimen was associated with acceptable adverse event rates after reduction of the vinorelbine dose …
Vinorelbine (Intravenous Route) - Mayo Clinic - Mayo Clinic
WebThe median dose delivered was 303 mg/m 2 for cisplatin and 236 mg/m 2 for vinorelbine, and the median relative dose intensities were 95% and 69%, respectively. There were 371 patients (43%) who did not complete chemotherapy because of patient refusal (42%), toxicity (30%), or unknown reasons (10%). WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … dns ipv4 primario xbox one
DRKS - Deutsches Register Klinischer Studien
WebJun 1, 1995 · Historically, drugs with modest reproducible single-agent activity in non-small-cell lung cancer have included cisplatin (Platinol), mitomycin (Mutamycin), ifosfamide (Ifex) , etoposide (VePesid), and the vinca alkaloids vinblastine and vindesine (Eldisine; available in Europe) [2,16-19]. WebThe IMPACT Japanese study compared gefitinib vs cisplatin vinorelbine in a phase III randomized control trial. 11 Adjuvant gefitinib appeared to prevent early relapse, but did not significantly prolong DFS or OS in patients with completely resected stage II–III, EGFR-mutated NSCLC. The apparent non-inferiority of DFS/OS may justify the use of ... WebAug 21, 2024 · Background Cisplatin and vinorelbine given intravenously is a well-established adjuvant chemotherapy regimen after surgery for early non-small cell lung cancer. However, few validated alternatives exist when cisplatin is not indicated or tolerated. Carboplatin is frequently used in this setting. We evaluated the 5-year overall … dns izbori 2022