WebEscherichia coli topoisomerase IV (Topo IV) is an essential ATP-dependent enzyme that unlinks sister chromosomes during replication and efficiently removes positive but not … Topoisomerase IV is one of two Type II topoisomerases in bacteria, the other being DNA gyrase. Like gyrase, topoisomerase IV is able to pass one double-strand of DNA through another double-strand of DNA, thereby changing the linking number of DNA by two in each enzymatic step. Both share a hetero-4 … See more Topoisomerase IV has two functions in the cell. • First, it is responsible for unlinking, or decatenating, DNA following DNA replication. The double-helical nature of DNA See more Topoisomerase IV is also a target of antibiotics, such as the quinolone drugs, which include ciprofloxacin. See more • DNA+Topoisomerase+IV at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more

WikiGenes - parC - DNA topoisomerase IV, subunit A

WebRationaldesignandsynthesisoftopoisomeraseIandIIinhibitorsbasedonoleanolicacidmoietyfornewanti-cancerdrugsAhmedAshourabSalehEl ... WebBased on in vitro efficiency, central nervous system (CPC) penetrance ability and feasible translational potential, two combinations using a DNA alkylating or topoisomerase inhibitors in combination with an ataxia telangiectasia mutated and rad3 (ATR) inhibitor (topotecan/elimusertib and melphalan/elimusertib respectively) were validated in vitro … chapter 246-215 wac

Topoisomerase IV tracks behind the replication fork and …

WebTopoisomerase IV (Topo IV) is a mediator of quinolone toxicity in bacteria. In this work, we demonstrate that norfloxacin, a model quinolone, converts Escherichia coliTopo IV into a … WebLecture 10: Cell Cycle. Outcomes: CC chromosomes, chromatids, homologous chromosomes Chromosome has two meanings: General: piece of DNA Specific: 2 sister chromosomes attached by a centromere; they are condensed during prophase and form an X shape Sister chromatids: 2 identical pieces of DNA connected at a centromere … WebMay 30, 2024 · [Source 16] Topoisomerase 2. Type II DNA topoisomerases are tetrameric proteins formed by two different subunits, GyrA2GyrB2 for gyrase and ParC2ParE2 for … chapter 246 320 wac