Thienopyridine derivatives
Web25 Apr 2024 · To develop of an effective synthetic methodology for biologically relevant thienopyridines, a concise and efficient protocol is described for the synthesis of a series of substituted thienopyridine and thienoquinoline derivatives with high selectivity using EtOCS2K as the sulfur source. The reaction proceeds via metal-free, site-selective C–H ... Web1 Nov 1997 · Clopidogrel is a thienopyridine that irreversibly inhibits platelet aggregation by selectively binding to adenylate cyclase-coupled ADP receptors on the platelet surface. In animal models, clopidogrel reduced the formation of both arterial and venous thrombi. After oral administration, clopidogrel is rapidly absorbed and undergoes metabolic ...
Thienopyridine derivatives
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WebThe thienopyridine derivatives (platelet adenosine diphosphate receptor antagonists), pharmacology and clinical developments Anaesthesia . 2003 Jan;58(1):28-35. doi: 10.1046/j.1365-2044.2003.02960.x. Web11 Sep 2007 · The high pharmacological potential of thienopyridine derivatives stimulates the elaboration of new ingenious methods, nonconventional approaches, and regio- and stereoselective procedures that ...
WebThe carboxarnide derivatives (X-XII) interacted with CS 2 giving pyridothienopyrirnidines (XX-XXII), while interaction with nitrous acid, pyridothienotriazines (XXIII-XXV) were produced. Key Words: Synthesis thienopyridine pyridothienopyrimidine pyridothienotriazine Web26 Oct 2024 · A series of thienotetrahydropyridine derivatives, in which the 2-position in the thiophene ring was blocked by substitution, for example, with an amino, carboxamido, ureido, or thioureido function, were …
WebComparing thienopyrimidine derivatives 2a–d, it was found that compound 2d acts as the most effective one, that is may be because of the presence of benzoyl-pyrimidinone moiety. Also, comparing thienopyridine compound derivatives 10a–d, one can say that compound 10a is the most effective one in this group. It may be because of the presence ... WebThis patent search tool allows you not only to search the PCT database of about 2 million International Applications but also the worldwide patent collections. This search facility features: flexible search syntax; automatic word stemming and relevance ranking; as well as graphical results.
Web25 Nov 2003 · Thienopyridine derivatives or thienodipyridine derivatives have been reported as anti-inflammatory drugs, especially as remedies for arthritis, in JP 8-225577 A (PCT International Application Publication No. WO96/14319); JP 10-36374 A (PCT International Application Publication No. WO97/40050), and PCT International Application Publication … fichier artxWebBackground Combinations of aspirin with thienopyridine derivatives (clopidogrel bisulfate or ticlopidine hydrochloride) and/or warfarin sodium are increasingly being used in various cardiac conditions. However, little is known about the bleeding risks associated with these combinations, particularly in elderly individuals at the population level. fichier articleWeb1 Apr 2005 · There are six isomeric thienopyridine structures, one of them being thieno[2,3-b]pyridine ( Fig. 1) and its derivatives which have since attracted attention due to their antitumor, antibacterial ... fichier as4aWeb27 Aug 2008 · Summary The thienopyridines, ticlopidine and clopidogrel, are antiplatelet drugs. They are prodrugs and are metabolised in the liver to active metabolites that are non-competitive antagonists of the platelet adenosine diphosphate receptor, P2Y 12.Inhibition of platelet aggregation by these drugs is delayed until 24–48 h after administration, with … grenfell tower inqWebThienopyridine Derivative Haematology. Thienopyridines act via inhibition of platelet activation by the ADP-dependent pathway without a direct... Preparation for endoscopy. Ian Penman, ... ... Thienopyridines (ticlopidine and clopidogrel) irreversibly suppress one... Anticoagulant and Antiplatelet ... fichier asciiThienopyridines are a class of selective, irreversible ADP receptor/P2Y12 inhibitors used for their anti-platelet activity. They have a significant role in the management of cardiovascular disease. See more They are used in the management of peripheral artery disease, as well as the prevention of coronary stent thrombosis and strokes. See more Drugs in this class include: clopidogrel (Plavix), prasugrel (Effient), and ticlopidine (Ticlid). Tinoridine was … See more Ticagrelor (Brilinta) is often listed with thienopyridine inhibitors and has similar indications for use but is not a thienopyridine. It is a … See more fichier as2Web16 Mar 2024 · Some new pyridinethione and thienopyridine derivatives have been synthesized and evaluated for their antiproliferative activity using the MTT assay. Nicotinamide derivatives 3 have been synthesized and used for the preparation of new condensed thieno [2,3-b]pyridines by their reactions with active halo compounds. Finally … fichier asar