2024 Uic2 antibody

Uic2 antibody

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August undefined, 2024

Web5 Oct 2024 · Human-specific MRK16 antibodies were expressed from hybridoma cells, cultured in Wheaton CeLLine Bioreactors following the producer’s recommendation, similar to the previously published UIC2 antibody method , followed by Protein G (GenScript) affinity purification and fragmentation using Fab Preparation Kit protocol (Thermo Fisher). The … WebEnter the email address you signed up with and we'll email you a reset link.

IM2370U, CD243-PE Conjugated Antibody, UIC2, 2 mL, ASR

WebThe drug-resistance phenotype of P-gp can be modulated by the monoclonal antibody UIC2, which specifically recognizes human P-gp in a conformation-dependent manner. Here, the purification, sequence determination and high-resolution structure of the Fab fragment of UIC2 (UIC2/Fab) are reported. Web19 Sep 2014 · The green fluorescence of FITC-UIC2 antibody was measured by a 530 ± 15 nm band-pass filter (FL1). Acquisition of data for 15,000 cells was gated to include viable cells on the basis of their forward and side light scatters and the propidium iodide (4 µg/mL) incorporation (propidium iodide interlaces with a nucleic acid helix with a resultant … how many grams in 1 cap of miralax

The Strong In Vivo Anti-Tumor Effect of the UIC2 Monoclonal …

Web13 Feb 2024 · Datasheets. MDR1/ABCB1 Antibody (UIC2) is a mouse monoclonal IgG 2a κ, cited in 31 publications, provided at 200 µg/ml. raised against MDR1 of human origin. … WebClone UIC2 is a strong inhibitor of CD243-mediated efflux and of the resistance of MDR cells to CD243 transported cytotoxic drugs. Clone UIC2 can be used in a shift assay to … WebThe mouse monoclonal antibody UIC2 recognizes an extracellular epitope on CD243 (MDR-1), an approximately 170 kDa ABC transporter expressed on hematopoietic stem cells, B, … hover focus 違い

Alexa Fluor® 647 anti-human CD243 (MDR-1) Antibody - BioLegend

Detection of P-glycoprotein-mediated multidrug resistance

Web27 Mar 2014 · Miele authored the 1997 Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products. In 1994, he … WebWithin the immune system, this molecule can be found on normal T, B, and natural killer cells, but not on monocytes. This antibody has been reported to inhibit MDR1-mediated efflux. Applications Reported: This UIC2 antibody has been reported for use in flow cytometric analysis. hoverfly uasWebEach lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application. hover focus active

"Web19 Sep 2014 · The UIC2 monoclonal antibody recognizes human Pgp and inhibits its drug transport activity. However, this inhibition is partial, since UIC2 binds only to 10-40% of cell surface Pgps, while the rest becomes accessible to this antibody only in the presence of certain substrates or modulators (e.g. cyclosporine A (CsA)). " - Uic2 antibody

Uic2 antibody

Use of photoimmunoconjugates to characterize ABCB1 in cancer …

WebThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. Application FC - Quality tested. Recommended Usage Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use ... WebInvitrogen Anti-P-Glycoprotein Monoclonal (UIC2), Catalog # MA5-44031. Tested in Immunohistochemistry (Frozen) (IHC (F)), Immunohistochemistry (Paraffin) (IHC (P)), …

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WebThe effect of HD37 on the function on P-gp pump appears to Previous studies by O’Connor et al. (6) and Liu et al. (7) involve a cytoplasmic pathway because, in contradistinction to demonstrated that an anti-CD19 IT increased the drug sensitiv- UIC2 and verapamil, the anti-CD19 antibody did not effect the ity of MDR lymphoma cells. WebProduct Specific Information. This antibody does not react with mouse or rat. Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of …

WebAPC Anti-P Glycoprotein antibody [UIC2] See all P Glycoprotein primary antibodies Description APC Mouse monoclonal [UIC2] to P Glycoprotein Host species Mouse Conjugation APC. Ex: 645nm, Em: 660nm Tested … WebThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. Application FC - Quality tested. Recommended …

Web13 Feb 2024 · MDR1/ABCB1 Antibody (UIC2) is a mouse monoclonal IgG 2a κ, cited in 31 publications, provided at 200 µg/ml. recommended for detection of MDR1 P-glycoprotien of human origin by IP, IF, IHC (P) and FCM; non cross-reactive with mouse and rat tissues. available conjugated to either phycoerythrin or FITC for IF, IHC (P) and FCM. Web27 Sep 2024 · UIC2 shift assay ( a) was used to evaluate the impact of verapamil, paclitaxel, and DAC-2Amide, -3Amide and -4Amide on P-gp conformation. Normalized median fluorescence intensity (MFI) upon...

Web19 Sep 2014 · The UIC2 monoclonal antibody recognizes human Pgp and inhibits its drug transport activity. However, this inhibition is partial, since UIC2 binds only to 10-40% of …

WebMouse monoclonal [UIC2] antibody to CD243 (Alexa Fluor® 647). Specificity. This antibody recognizes an extracellular epitope on CD243, an approximately 170 kDa ABC transporter … hover font color cssWebIntroduction On January 6, 2024, lecanemab (Leqembi) was granted accelerated approval by the United States Food and Drug Administration (FDA) for the treatment of early Alzheimer disease (AD). 1 The second in its class, lecanemab is preceded by the controversial amyloid beta-directed monoclonal antibody, aducanumab (Aduhelm). Like aducanumab, … hover font weight boldWebThe UIC2 monoclonal antibody specifically binds to an extracellular epitope of CD243, which is also known as ATP-binding cassette subfamily B member 1 (ABCB1), Multidrug resistance protein 1 (MDR1), or P-glycoprotein 1. CD243 is a transmembrane glycoprotein that spans the membrane 12 times. hover football bootsWebUIC2 is a monoclonal antibody that binds to the extracellular region of ABCB1, particularly extracellular loops 1, 3 and 4 [ 29 ]. Thus, it allows for labeling of cell surface-expressed ABCB1 without disrupting the plasma membrane. hover follow you droneWebBuy mouse monoclonal (UIC2) antibody to CD243 (A121698). Validated Applications: Flow Cytometry. Reactivity: Human. ️ Low Prices ️ 100% Guarantee hover font awesome icons hoverfootWebUIC2 is a mouse monoclonal antibody directed against the extracellular conformational epitope of P-glycoprotein (Pgp). This antibody can be used in flow cytometry, … how many grams in 1 carbohydrate